The game takes place in Manhattan, New York City ten years after the events of Parasite Eve II. The player takes on the role of Aya Brea, and must fight against mysterious "Twisted" creatures threatening the city.
The story follows New York City police officer Aya Brea over a six-day span in 1997 as she attempts to stop the monster that is sparking the creation of a creature that will destroy the human race through spontaneous human [...]
Three years after the Manhattan incident, in September 2000, Aya Brea is an FBI agent working in the Mitochondrion Investigation and Suppression Team (MIST) and has been dispatched on an urgent mission in Los Angeles, [...]