Saints Row 2 is an 'open-world' action game in which players assume the role of gang members set on re-establishing their former glory in the fictionalized urban setting of Stilwater. Missions primarily involve destroying rival gangs and their members by any means necessary: Players can attack and kill characters using pistols, chainsaws, baseball bats, knives, flamethrowers, and night sticks. Players can also roam 'off-mission' and kill non-adversaries (e.g., pedestrians, shop-keepers, homeless people, etc.) at any time. Collateral damage includes spurts of blood when characters are shot, stabbed, or bludgeoned and extensive post-mortem violence (e.g., players can keep shooting at dead bodies, causing them to flail and emit more blood; players can earn 'respect points' for taunting dead human corpses). One cutscene depicts a character holding a decapitated head over a railing. The game features cutscenes and missions that contain depictions of sexual behavior: One cutscene depicts a woman's head moving out of screen and into a gang member's lap – suggesting fellatio; Intercourse is implied as players drive around a prostitute who "performs" with a client in the back seat. Certain missions involve drugs – delivering, selling or arranging transactions –, while players can also purchase marijuana blunts, which can impair the player's vision through a 'screen-blur' effect. Players can also hear strong profanity throughout the game (e.g. "f*ck,""sh*t,""c*nt," etc.).

The content of this game is suitable for persons aged 18 years and over only. It contains: Extreme violence - Multiple, motiveless killing - Violence towards defenceless people - Glamorisation of drugs - Strong language - Content that teaches or encourages gambling This game allows the player to interact with other players ONLINE.