Biotope system requirements state that you will need at least 2 GB of RAM. If possible, make sure your have 4 GB of RAM in order to run Biotope to its full potential. In terms of game file size, you will need at least 950 MB of free disk space available. An Intel Core 2 Duo T7250 CPU is required at a minimum to run Biotope. Whereas, an Intel Core 2 Quad Q9650 is recommended in order to run it. Provided that you have at least an NVIDIA GeForce 8200M G graphics card you can play the game. But, according to the developers the recommended graphics card is an AMD Radeon HD 5450.
Biotope will run on PC system with 32-bit Windows 7 and upwards. Additionally it has a Mac version.