SLICE system requirements state that you will need at least 256 MB of RAM. If possible, make sure your have 512 MB of RAM in order to run SLICE to its full potential. The cheapest graphics card you can play it on is an NVIDIA GeForce 6100. In terms of game file size, you will need at least 300 MB of free disk space available. To play SLICE you will need a minimum CPU equivalent to an Intel Core 2 Duo U7600.
SLICE will run on PC system with 7 and upwards. Additionally it has Mac and Linux versions.