In terms of game file size, you will need at least 200 MB of free disk space available. Silicone-2 system requirements state that you will need at least 2 GB of RAM. To play Silicone-2 you will need a minimum CPU equivalent to an Intel Core 2 Duo U7600. The cheapest graphics card you can play it on is an NVIDIA GeForce GTS 250.
Silicone-2 will run on PC system with Windows XP, Vista, 7 and upwards. Additionally it has a Linux version.