TIS-100 system requirements state that you will need at least 2 GB of RAM. Provided that you have at least an NVIDIA GeForce 510 graphics card you can play the game. You will need at least 100 MB of free disk space to install TIS-100. An Intel Pentium 4 2.00GHz CPU is required at a minimum to run TIS-100.
TIS-100 will run on PC system with Windows XP / Vista / 7 / 8 / 10 and upwards. Additionally it has Mac and Linux versions.