You will need at least 150 MB of free disk space to install Twixel. Twixel system requirements state that you will need at least 2 GB of RAM. If possible, make sure your have 4 GB of RAM in order to run Twixel to its full potential. An Intel Core 2 Duo E8400 CPU is required at a minimum to run Twixel. Provided that you have at least an Intel 82945G Express graphics card you can play the game.
Twixel will run on PC system with Windows 7 and upwards. Additionally it has a Mac version.