SQUAKE system requirements state that you will need at least 3 GB of RAM. The cheapest graphics card you can play it on is an AMD Radeon HD 6750M. In terms of game file size, you will need at least 200 MB of free disk space available. To play SQUAKE you will need a minimum CPU equivalent to an Intel Core 2 Duo E6850.
SQUAKE will run on PC system with Windos 7, Windows 8/8.1, Windows 10 and upwards. Additionally it has a Mac version.