To play Metrocide you will need a minimum CPU equivalent to an Intel Core 2 Duo T5850. Whereas, an Intel Core i5-650 is recommended in order to run it. The cheapest graphics card you can play it on is an NVIDIA GeForce 510. Metrocide system requirements state that you will need at least 512 MB of RAM. Additionally, the game developers recommend somewhere around 1 GB of RAM in your system. In terms of game file size, you will need at least 200 MB of free disk space available.
Metrocide will run on PC system with Windows 7 and upwards. Additionally it has a Mac version.