You will need at least 9 GB of free disk space to install Syndrome. The cheapest graphics card you can play it on is an ATI Radeon HD 5750. But, according to the developers the recommended graphics card is an ATI Radeon HD 5970. To play Syndrome you will need a minimum CPU equivalent to an Intel Core 2 Duo E8400. Syndrome system requirements state that you will need at least 4 GB of RAM. If possible, make sure your have 8 GB of RAM in order to run Syndrome to its full potential.
Syndrome will run on PC system with Windows Vista 64-bit and upwards. Additionally it has a Mac version.
Note
If you are using a game controller, you need to plug it before launching the game. Only Xbox One controller is supported. Others controllers might not work.