Provided that you have at least an NVIDIA GeForce 510 graphics card you can play the game. Sam & Max 106: Bright Side of the Moon system requirements state that you will need at least 4 GB of RAM. An Intel Core 2 Duo E8400 CPU is required at a minimum to run Sam & Max 106: Bright Side of the Moon.
Sam & Max 106: Bright Side of the Moon will run on PC system with and upwards.
Show Sam & Max 106: Bright Side of the Moon system requirements on your site