Provided that you have at least an NVIDIA GeForce 6200 graphics card you can play the game. An Intel Pentium 4 2.00GHz CPU is required at a minimum to run Afterlife. In terms of game file size, you will need at least 250 MB of free disk space available. Afterlife system requirements state that you will need at least 256 MB of RAM. Additionally, the game developers recommend somewhere around 512 MB of RAM in your system.
Afterlife will run on PC system with Windows XP or newer and upwards. Additionally it has a Mac version.